What severe consequence can prolonged cocaine use lead to?

Prolonged cocaine use can lead to respiratory failure, which is a severe consequence of this substance's impact on the body. Cocaine is a powerful stimulant that affects the central nervous system and can cause significant cardiovascular issues, including the constriction of blood vessels and increased heart rate. These effects can lead to serious respiratory complications, particularly when cocaine is smoked or used in conjunction with other substances that further depress the respiratory system.

While the other options present various health risks associated with drug use, respiratory failure specifically highlights a critical and potentially life-threatening outcome from extended cocaine use due to its direct effects on the body's ability to function properly. It underscores the severe risks users face, particularly regarding the respiratory system, which can lead to insufficient oxygenation of the body and ultimately result in fatal consequences.